Can I take CBD with other medications?

When ingested orally in sufficient quantities, CBD momentarily alters the action of cytochrome P450, which can affect the metabolism of a wide variety of compounds, up to 60% of commonly prescribed drugs.

Any medicine that is metabolized by the P450 enzyme can be affected by CBD, but this does not necessarily mean that there will be an interaction with CBD.

Substances that use the cytochrome P450 system include:

  • Steroids
  • HMGCOA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • Antivirals-histamines
  • Immunomodulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anesthetics
  • Antidepressants
  • Antiepileptics
  • Beta blockers
  • Proton pump inhibitors
  • Non-steroidal anti-inflammatory drugs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

You should consider consulting a doctor if you have concerns about the impact of your prescribed medications.